A Technical Advisory Group (TAG) meeting in Kabul reviewed Afghanistan’s polio eradication strategy, focusing on site-to-site vaccination and challenges in stopping wild poliovirus (WPV1) transmission. This meeting, the first in seven years within Afghanistan, highlighted the urgent need to protect progress. TAG endorsed the “Strategic Reset” to improve vaccination campaigns but emphasized stronger leadership, community engagement, and government support. While the eastern region shows progress, transmission persists in the southern corridor due to population movement with Pakistan. The shift to site-to-site vaccination has increased missed children, requiring better community outreach. TAG set goals for 2025, including eliminating virus lineages in the East and controlling the outbreak in the South. Recommendations include engaging local leaders, improving community mobilization, and implementing “Pluses” to boost vaccine uptake. Afghanistan has a chance to end polio by 2025 with strong leadership and regional cooperation.