A startling finding regarding the long-term use of the sleep supplement Melatonin has emerged from a preliminary study presented at the American Heart Association’s Scientific Sessions 2025. According to the research, prolonged use of Melatonin may lead to a significant increase in the risk of developing heart failure.
Key Findings of the Research:
Researchers analyzed five years of medical records for over 130,000 adults suffering from insomnia, using the TriNetX Global Research Network. The results indicated:
- Heart Failure Risk: Individuals who used Melatonin for one year showed a 90 percent higher risk of heart failure.
- Hospitalization and Mortality: These users faced a 3.5 times higher risk of hospitalization due to cardiac events, along with an elevated overall risk of mortality.
The study suggests that long-term Melatonin use heightens the possibility of serious heart diseases, which may require emergency medical attention and could prove fatal.
Expert Concerns:
Experts note that Melatonin is not an approved drug for the long-term treatment of insomnia in the United States. Furthermore, because it is an unregulated supplement, its potency and purity can vary significantly between brands, posing potential risks to consumers.
The researchers acknowledged that while the results signal clear risks to cardiac health associated with extended Melatonin use, the cause-and-effect relationship has not yet been definitively proven. They emphasized the critical need for further comprehensive research to clarify the true nature of Melatonin’s effects on the heart over the long term.
