Colorectal cancer is the second leading cause of cancer-related deaths worldwide, with early detection playing a critical role in reducing mortality. One of the most effective methods for early detection is colonoscopy screening. However, a recent trial called the **NordICC (Nordic-European Initiative on Colorectal Cancer) trial** has sparked debate, with some interpreting its results as suggesting that the benefits of colonoscopy might be overestimated. But is this really the case? In this blog, we explore why the benefits of screening colonoscopy may still be underestimated, despite the findings from the NordICC trial. ### Understanding the NordICC Trial The NordICC…
Author: Raja Zahid Khanzada
Mismatch repair (MMR) and microsatellite instability (MSI) testing has increased among patients with colorectal cancer (CRC) from 22.7 percent in 2012 to 71.5 percent in 2021. However, there are still access issues, with testing rates varying depending on the stage of the cancer, the individual hospital, the patient’s sex, race, and insurance status. METHODOLOGY: Although studies indicate that testing may still be underused, the National Comprehensive Cancer Network (NCCN) recommended universal MMR and MSI testing for CRC patients in 2017. Researchers looked at 834,797 patients who were diagnosed with stage I to IV CRC between 2012 and 2021 at 1366…
After being accused of rape and sexual assault in an Australian court, British YouTuber and singer Yung Filly, whose real name is Andrés Felipe Valencia Barriento, was granted bail. The 29-year-old was accused of four counts of sexual penetration without consent, three counts of assault that resulted in bodily harm, and one count of obstructing breathing. Following his performance at Bar120 nightclub on September 27, the alleged incident took place in a Perth hotel on September 28. This week, Barriento was taken into custody in Brisbane and extradited to Perth, where he appeared in court. PA claims that during his…
Jennie, who is a member of BLACKPINK, has released her new solo video for the song “Mantra.” The video is heavily influenced by the action-comedy film Rush Hour, which came out in 1998. As a nod to the classic film, the video begins with a scene that resembles an opening scene. Jennie demonstrates her signature fashion style throughout the video by posing with a variety of classic cars in various Los Angeles locations, alluding to the setting of Rush Hour. Jennie is seen in a number of scenes driving color-coordinated vehicles, such as lounging in a blow-up swimming pool, dancing…
The new selection committee will announce the Pakistani national team for the upcoming white-ball tour of Australia, which will be announced by the Pakistan Cricket Board (PCB). Former cricketers Azhar Ali and Aaqib Javed are likely to join the panel, according to sources. Both have indicated that they are willing to work together with the PCB on projects that go beyond team selection and aim to develop the squad’s young talent. Aleem Dar, a former elite umpire for the International Cricket Council, is also expected to be appointed to the new committee. This follows Mohammad Yousuf’s resignation as captain, which…
Over allegations of “anti-competitive” behavior, Lionel Messi’s drink company, Mas+ by Messi, Logan Paul, and KSI’s Prime Hydration are engaged in a legal dispute. Mark Anthony International, the distributor of Mas+, filed a lawsuit on October 8, 2024, claiming that their packaging does not violate Prime’s design and seeking a declaratory judgment. Prime Hydration is said to have demanded that Mas+ stop selling unless the drink’s packaging was changed, which led to the legal action. According to the lawsuit, Prime also threatened to sue Mas+ for trademark and trade dress infringement, which prompted Mas+ to defend their brand. A survey…
Captain Shan Masood mourned the group’s failure to tie down a success after a dampening rout to Britain in the primary Test in Multan, where they neglected to exploit major areas of strength for an innings all out of 550. England won the match by an innings and 47 runs. This was Pakistan’s sixth loss in a row in a Test match. It is important to note that Pakistan is the first team in 147 years to lose by an innings after scoring 500 runs in a Test match. Masood remarked, “We’ve spoken about the third innings or fourth innings,…
The star Indian batsman Virat Kohli returned from London last night to prepare for the upcoming Test series against New Zealand. He arrived in Mumbai last night. The 35-year-old man was spotted at Mumbai’s airport, where he stopped to pose for pictures with photographers before heading out. The photographers made a lighthearted joke about Kohli, telling him, “BGT mein aag lagani hai” (You have to light up the Border-Gavaskar Trophy). On Wednesday, October 16, the three-match Test series between India and New Zealand is scheduled to begin in Bengaluru. On October 24, the second Test will take place in Pune,…
In a statement that raises questions about the effectiveness of the regulatory framework, Finance Minister Muhammad Aurangzeb said on Thursday that Pakistan’s large corporate firms and their white-collar management were involved in a staggering Rs3.4 trillion annual sales tax fraud. Aurangzeb stated during a press conference held at the Federal Board of Revenue (FBR) headquarters that the FBR has established fraud worth Rs227 billion in five major industries. The finance minister stated that tax evasion and fraud had resulted in a tax gap of Rs3.4 trillion, adding that tax evasion could be measured by the fact that only 14% of…
The Federal Board of Revenue (FBR) has made the decision to raise property values by as much as 75%. According to FBR sources, property valuations have been determined for 42 major cities across the nation, and the revised prices have been finalized. It is anticipated that a notification regarding the new property valuations will be issued soon. The location and fair market value have been used to calculate the valuations. The new property valuations for an additional 15 cities will be added to the list in the following phase. Rashid Langrial, Chairman of the Federal Board of Revenue (FBR), issued…
